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For example, PEG-lipopeptides like mPEG2k-Glu(C 16 ) 2 have the right balance between low cytotoxicity and good pDNA/siRNA transfection activity.47,48 It was noticed that cholesterol-based PEGylated lipoplexes tend to accumulate mainly in hepatic tumors49 and may have great potential in gene therapy of liver diseases

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